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The selective autophagy substrate p62 activates the stress responsive transcription factor Nrf2 through inactivation of Keap1

Overall, more studies are needed to further clarify the precise role of these time-dependent events in AILI, thus making the late phase therapy become possible in clinical

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These results as mentioned above indicate that targeting VEGF may represent an effective key factor to deter the subsequent and deleterious effect of activation of its downstream molecular pathways

J Pharmacol Exp Ther 318:521529 Baeuerle PA, Baichwal VR (1997) NF-kB as a frequent target for immunosuppressive and anti-inflammatory molecules
