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Butcher MJ et al

The SLR identified 8 additional articles reporting favorable outcomes with extracorporeal treatments in most cases

Sphingosine kinase-1 involves the inhibitory action of HIF-1 by chlorogenic acid in hypoxic DU145 cells

& van der Spuy, Z
doi: 10.1080/01635581.2011.539311

This is also the case for desferrithiocin, which has been shown to be a potent iron chelator, but also demonstrated toxicity in animal studies (Nick et al., 2003)
