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E., and Harding, J

Notably, L -2HG is 17-fold more potent than D -2HG in inhibiting -KG-dependent dioxygenases, impairing L2HGDH activity, and stabilizing HIF-1, thereby reinforcing hypoxic and acidic cellular conditions (98)

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Furthermore, the knockdown of TGFb-associated genes abolished the adverse effects evoked by TGFb ligands

Pterostilbene further enhances the anti-aging effects by inhibiting the mTOR pathway and activating AMPK, leading to improved metabolic function and longevity
