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The topology of this release, whether into the matrix or intermembrane space, determines subsequent reaction pathways and target accessibility, establishing these sites among the best-characterized endogenous radical sources in mammalian cells [1621]

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Such drugs therefore need to be administered at more frequent dosing intervals

Metabolomics, an advanced and rapidly developing technical field, provides highly effective methodologies for in-depth analysis of the complex interaction mechanisms between amino acid metabolism and CHD