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(14) Just this month, June 2016, a meta-analysis of 11 prospective studies, including 29,155 participants, found significant inverse association between highest coffee consumption and the risk for Alzheimers disease a 27% reduction in risk
This happens because of: Enzymatic breakdown Stomach acid (pH instability) First-pass metabolism in the liver As a result, oral peptides rarely reach the bloodstream in effective amounts
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2017 Dec;164(2):140-143
Alternative pharmacological methods of treating pain are available
