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used VPA, Parnate, TTNPB, and Dznep combining with other small molecules to induce direct reprogramming from MEFs to iHeps with only a single factor FOXA3 (Li et al., 2017b)

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The second is dose and route translation : even where an effect is real in a mouse, the human-equivalent dose is not a simple body-weight scaling, and as the route section above stressed there is no human bioavailability figure to anchor an oral-versus-injected comparison

They found 35 studies that were all done on laboratory animals 35

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