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Cheers, Ben

Cham, Switzerland: Springer

We set out to develop biochemical biomarkers of target engagement (a direct measure of drug action) to measure the effects of therapies targeting oxidative stress, including edaravone and nuclear factor erythroid 2-related factor 2 (NRF2) activators [3], which show promise as disease-modifying agents for neurodegenerative diseases

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Figures 27 A & B indicate that those analogs that were previously found to block HGF dimerization were effective inhibitor of HGF/Met mediated cell scattering in MDCK cells, while those analogs with poor affinity for HGF were ineffective