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The potential mechanisms driving obesity-mediated enhancement of cancer growth in this study mainly included TAMs-associated adipose inflammation and the release of adipose specific IGF-1 ( However, despite such observations and the well-established epidemiological link between obesity and the severity of prostate cancer ( 4 Tumor microenvironment, tumorigenesis and drug resistance Tumor microenvironment highly active cells, and in particular adipose tissue and TAMs, are potential determinant for a driving role of obesity and other risk factors in cancer development