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HFpEF patients were found to have significantly higher troponin levels at rest, with the degree of elevation directly correlated to higher pulmonary capillary wedge pressure and worse systolic and diastolic tissue Doppler velocities

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Lactobacillus reuteri , which had a lower abundance in HFpEF rats, has also been shown to be able to mitigate cardiac injury in high-fat-induced rat models of obesity [55]