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Homocysteine inhibits pro-insulin receptor cleavage and causes insulin resistance via protein cysteine-homocysteinylation

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To identify pathways that were altered by vB12 treatment, we performed a pathway analysis (using a DAVID functional annotation tool) of up-regulated and down-regulated genes separately for each of the three categories of DEGs

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An exciting target to study TRPA1 is Mller glia, which express TRPA1 (de Arajo et al., 2020), and show oxidative stress as an early response to hyperglycemia conditions, upregulating VEGF (Rossino et al., 2020), which contributes to the injurious events in DR, such as increased endothelial permeability, angiogenesis, and apoptosis (Wang et al., 2015)

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