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The Arg1038Gly missense variant in the NF1 gene causes a mild phenotype without neurofibromas

These research outcomes support the role of ferroptosis in RBI and offer promising targets for future clinical interventions

Oxidative stress and ROS generation Many ototoxic drugs, particularly aminoglycosides and platinum-based chemotherapeutics, induce oxidative stress by increasing ROS production

10.1152/ajpcell.00179.2004 [DOI] [PubMed] [Google Scholar] Gu Y-H, Kodama H, Murata Y, Mochizuki D, Yanagawa Y, Ushijima H, Shiba T, & Lee C-C (2001)

One might expect that exposure of case subjects could have been overestimated because physicians more aggressively sought symptoms and exposure reports, although this was not possible for the deceased cases

Individual variation in medication tolerance is normal