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Hydroxychloroquine (HCQ) and proton pump inhibitors have been identified as inhibitors of autophagy because of their ability to block lysosomal acidification and autophago-some degradation (Marino et al, 2010)

LPAAT activity of ABHD5 has been reported (22, 81)

Subsequent immunohistochemistry (IHC) analysis revealed that the inhibitory effects on tumor growth were accompanied by a marked reduction in HER2 intensity and a decreased number of Ki67-positive cells in the tumor tissue treated with YK1 (Fig

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31 This modification can trigger alterations in DNA conformation, DNA stability, chromatin structure, and the interplay between DNA and proteins, thereby exerting a regulatory influence on gene transcription

PMID 10730193
