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So, often, the progression of the research went something like this: Start with a crude organ extract Observe biological effects Isolate the smallest peptide sequence responsible Synthesize it Thats actually a very reasonable scientific approach

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Mice were challenged after 21 days by intradermal immunization in the base of the tail with this emulsion

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[DOI] [PubMed] [Google Scholar] 154.Wermuth L, Bech P

Concurrently, a clinical study involving 98 pSS patients and 105 healthy controls (208) found that butyrate-producing bacteria were significantly reduced in pSS patients, and this reduction correlated negatively with increased Th17 cells and an imbalance in Th17/Treg