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Acknowledgements This work was supported by the State Scholarship Fund from China Scholarship Council (N o 201206370103), the National Natural Science Foundation of China (N o 81273595, 81072706, and 84402511), the Scientific Foundation of Hunan (N o 11K073 and 10JJ4020), the 863 Project (N o 2012AA02A518), NCET-10-0843 and the Research Innovation Foundation of Graduate Student in Hunan province, China (CX2011B056)

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Children with ASD also have significant decreases in methionine levels and the ratio of plasma S-adenosylmethionine (SAM) to S-adenosylhomocysteine (SAH) (SAM: SAH ratio), an index of methylation capacity (16, 21, 22)