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Pain 159 , 26582666 (2018)

& Patil, R

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The following occurred in the respective cases: sodium and chloride depletion fluid overload septicemia, or blood poisoning, in an individual with existing compromised liver function and portal hypertension While underlying conditions may have increased the risk of severe side effects or death in some cases, these findings suggest that coffee enemas are generally not safe

Laboratory factors such as macro-B12 (immunoglobulin-bound B12) can cause spurious elevation on some assays