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Future medicinal chemistry efforts may yield next-generation compounds with enhanced properties, including improved tissue selectivity, modified pharmacokinetics, or additional mechanistic activities that complement NNMT inhibition

Bulboac et al

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The papillary dermis is where fibroblasts respond to mechanical injury by triggering the wound-healing cascade and to GHK-Cu, PDRN, and growth factors by initiating collagen synthesis [2]