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Given that previous studies have shown that Chac2 can functionally antagonize Chac1-mediated GSH degradation, likely due to its slower catalytic turnover and distinct substrate-binding properties, and supports a model in which CHAC2 competitively binds reduced GSH but degrades it inefficiently, thereby favoring net GSH retention

The purpose of the antioxidant system is to protect the body against excessive and uncontrolled cell oxidation

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Disruption of 12/15-lipoxygenase expression in peritoneal macrophages

Increased risk of toxicity of tricyclic antidepressants is likely in patients whose CYP2C19 and/or CYP2D6 activities are diminished

2000;24(2):S109-12