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In a hypoxic environment, peroxynitrite production activates HIF-1, which is associated with the Wnt/-catenin signaling pathway, leading to the promotion of neural stem cell proliferation, self-renewal, and neuronal differentiation
[DOI] [PMC free article] [PubMed] [Google Scholar] 210.Tsuboi K., Bachovchin D.A., Speers A.E., Brown S.J., Spicer T., Fernandez-Vega V., Ferguson J., Cravatt B.F., Hodder P., Rosen H
Because of the high penetrance and aggressive nature of this malignancy, patients identified with a known RET mutation should undergo a prophylactic thyroidectomy early in life to prevent metastatic disease
Furthermore, to guarantee efficacy and reproducibility, clinical validation and standardization of nutraceuticals are necessary
PubMed Central , Communications Biology , vol
10.1017/S004393391500029X 57
