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This educational page outlines a subcutaneous approach on an empty stomach, with a dilution chosen so doses land on easy-to-read insulin-syringe marks

It produces worse side effects, more discontinuations, and often slower progress because severe GI symptoms prevent adequate nutrition and hydration

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Contracture occurred whether rats were awake/anesthetized and persisted after sacrifice

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The rationale is mechanistic (complementary pathways with no known antagonism) and supported by clinical experience from physicians who prescribe both