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Food and Drug Administration has approved the use of L-carnitine in hemodialysis patients for the prevention and treatment of L-carnitine deficiency

This suggests that the delicate balance between pro-oxidants and antioxidants is crucial, and that the antitumor effect of HTX may involve mechanisms in addition to antioxidant action, possibly related to the modulation of intracellular signaling pathways influenced by hormonal status, especially in hormone-dependent tumors [45,62,98,100,101,103]

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Sirt3 mediates reduction of oxidative damage and prevention of age-related hearing loss under caloric restriction

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169,170,171 The activation of LOX/LOXL stimulates signaling pathways involving protein kinase C and protein tyrosine kinase 2, further driving the activation of transcription factors associated with cancer cell proliferation and metastasis