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Metal-Protein Attenuation with Iodochlorhydroxyquin (Clioquinol) Targeting A Amyloid Deposition and Toxicity in Alzheimer Disease: A Pilot Phase 2 Clinical Trial

Taken together, these findings suggest that exposure to trauma may be associated with mitochondrial dysfunction and increased ccf-mtDNA due to increased ROS production and cellular injury, but that chronic PTSD is defined by mitochondrial loss and thus a delayed decrease in ccf-mtDNA to a new, lower baseline level

10.1016/j.phymed.2025.156715 219

These data indicate that the pathologic disruption of dopamine regulation, possibly through alterations in prolactin release, could dysregulate osteoblast and osteoclast function and influence bone resorption and mineralization