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A member of the RAS superfamily, ADP ribosylation factor 6 (ARF6), acts as a downstream of the KRAS/extracellular signal-regulated kinase (ERK) pathway to increase the proliferation and Warburg effect of pancreatic cancer cells

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Hollow dark circles are the most challenging to treat, although solutions do exist

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doi: 10.2174/1389450115666141024113925

It is a global problem that seriously threatens human health