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Patients with known or suspected mitochondrial disease:  Valproate induced acute liver failure and liver-related deaths have been reported in patients with hereditary neurometabolic syndromes caused by mutations in the gene for mitochondrial DNA polymerase (POLG) (e.g., Alpers-Huttenlocher Syndrome) at a higher rate than those without these syndromes (see Contraindications)

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Glial cells play a central role in this process by initiating, modulating, and ...

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