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Antihistamines like famotidine and cetirizine (Zyrtec) address one downstream symptom of the flush, the histamine-driven redness, but they do nothing about the acetaldehyde buildup that caused the histamine release in the first place

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Am J Clin Nutr 80:16111617 Moumen R, Nouvelot A, Duval D, Lechevalier B, Viader F (1997) Plasma superoxide dismutase and glutathione peroxidase activity in sporadic amyotrophic lateral sclerosis

Antioxidants are molecules that capture free radicals

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Functionally, each pathway circumvents melanomas intrinsic apoptosis resistance, and their dysregulationvia genetic mutations, epigenetic silencing, or metabolic reprogrammingcontributes to tumor progression and therapeutic resistance, highlighting their shared role as tumor-suppressive mechanisms when functionally intact (112, 114)
