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Obstetric Disorders and Critical Illness

2012 Feb;44(2):168-74

[Abstract] Acta Pharmacol Sin

Standard dosing protocol Dose range : 1-3mg daily Most common : 2mg daily for therapeutic use Conservative start : 1mg daily for first week, assess tolerance High dose : 3mg daily for acute inflammation or intensive healing Frequency : Once daily, preferably same time each day Reconstitution Standard protocol : Add 2ml bacteriostatic water to 50mg vial Concentration : 25mg/ml Dose calculation examples : 1mg dose = 0.04ml (4 units on insulin syringe) 2mg dose = 0.08ml (8 units) 3mg dose = 0.12ml (12 units) 50mg vial lasts : 25-50 days depending on dose Use our reconstitution calculator for exact measurements

Children with low vitamin D may have reduced RFC function, meaning even high-dose Leucovorin may not work effectively

Ekstrapolacja tych dawek na ludzi, przy uyciu standardowych czynnikw konwersji allometrycznej (czynnik 6,2 dla szczurw), daje teoretyczne dawki rzdu 1,6 g/kg u ludzi