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Description
This major upstream regulatory element, located 3070 kb upstream of the -globin genes, regulates the expression of genes in the -globin cluster (136, 137)

Rosique-Esteban N, et al
Walker RF, Codd EE, Barone FC, et al

36 , E1E150 (2015)
The prolonged activation of macrophages and microglia has been associated with the increased production of ROS (Hemmati et al., 2020) and eventually results in oxidative stress (Zhang et al., 2020)
Pro-tumorigenic roles of fibroblast activation protein in cancer: back to the basics