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L-Citrulline works by way of converting into arginine and has been known to increase nitric oxide & plasma arginine levels at a higher rate than L-Arginine itself due to the first pass effect where most arginine gets metabolized in the stomach prior to reaching the bloodstream

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Despite calcium, glucagon, high-dose insulin (HDI), and lipid emulsion for calcium channel blocker and bicarbonate for metabolic acidosis, the patient remained hemodynamically unstable

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