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However, the largest Phase IIb trial involving 536 participants failed to demonstrate statistically significant weight loss compared to placebo at the primary 12-week endpoint, leading to development termination in 2007

Low-to-moderate intensity cardio (brisk walking, cycling at conversation pace, light jogging) performed in this window maximizes fat oxidation because the exercise intensity keeps the body in a predominantly fat-burning metabolic state

In one large study, 39% of patients with deficiency had neurologic manifestations, and in almost 80% of these cases, the neurologic symptoms were the sole or dominant manifestation of the deficiency (96)