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Tolerance to the neuroplasticity effects has not been documented in research models, meaning repeated dosing continues to drive synaptic remodeling without requiring higher doses to achieve the same receptor activation

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doi: 10.1042/CS20160897

In addition, we calculated the ratios of these metabolites to the level of N-acetyl aspartate (NAA), which is exclusively localized in neurons

doi: 10.1371/journal.pone.0096508 73 HuangSCEvertsBIvanovaYOSullivanDNascimentoMSmithAMet al