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Klotho levels decline significantly with age: young adults (18-35) have the highest levels, with progressive decreases through middle age and into older adulthood

Pharmacologic anti-inflammatory therapy is reserved for selected patients and should be considered only by a qualified clinician who can weigh cardiovascular benefit against infection, gastrointestinal, kidney, liver, bleeding, and medication-interaction risks

Li DX, Deng TZ, Lv J, Ke J

It has been tested in animals and human test subjects

Even then, the body has regulatory mechanisms to prevent accumulation

And this makes sense the FDA wants to incentivize products going through the rigorous approval process to ensure safety and efficacy