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Contraindications include active infection at the injection site, severe thrombocytopenia, or anticoagulation therapy requiring provider clearance

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Symptoms of vitamin B12 deficiency include: fatigue, irritability, anxiety, low energy, depression, forgetfulness, constipation, new food sensitivities, hot and cold flashes, sore muscles, pale skin, numbness, tingling, and dermatitis

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Patients with persistent symptoms, including those with PTLD, have also been studied using various neuroimaging modalities including MRI (121, 122), SPECT (123, 124), and PET (125) scanning techniques