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Zhou Z., Lin Y., Gao L., Yang Z., Wang S., and Wu B., Circadian Pharmacological Effects of berberine on Chronic Colitis in Mice: Role of the Clock Component Reverbalpha, Biochemical Pharmacology 172 (2020): 113773

Under stressed conditions, the stressors that are usually oxidative or electrophilic molecules react with the cysteine residues of Keap1 to cause conformational changes in Keap1, leading to downregulation of Keap1-mediated ubiquitination and degradation of Nrf2

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doi: 10.1371/journal.pgen.1000437

Visual check: Solution should be clear, colorless (unless B12 is present), and free of visible particles