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Author contributions MK, TB, JH, MM, LH, KK, RP, and SK designed and carried out experiments

While clinical interactions have not been documented, combining multiple compounds that affect similar pathways increases unpredictability

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If the 4 mg maintenance arm proves non-inferior for weight maintenance in Phase 3, researchers may be able to titrate up to a high working dose during the active weight-loss phase, then step back down to a lower 4 mg maintenance dose for the long stabilization phase