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In HCC pathogenesis, this likely does not constitute the initial oncogenic event but may lower the genomic fidelity of hepatocytes, facilitating the accumulation of mutations and accelerating the evolution of initiated clones within the chronically injured liver

Polymeric Nanoparticles Polymeric nanoparticles are gaining increasing attention for pulmonary drug delivery, as their polymeric structure can be conjugated with specific groups to enable efficient delivery of therapeutic agents [124, 125]

Multifunctional roles and pharmacological potential of -sitosterol: emerging evidence toward clinical applications

Proc Natl Acad Sci U S A (2007) 104:1228893.10.1073/pnas.0701549104 79 MandalPKSchneiderMKollePKuhlencordtPForsterHBeckHet alLoss of thioredoxin reductase 1 renders tumors highly susceptible to pharmacologic glutathione deprivation