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While safe at therapeutic doses of up to 4 g per day for adults, APAP overdoses, either accidental or intentional, are one of the leading causes of acute liver failure in the United States [33]

International Journal of molecular sciences (2021) 23(1):426

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Erastin can directly bind to VDAC 2 and alter mitochondrial membrane permeability, thereby inducing nonapoptotic cell death [48]

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