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Experimental ferrets were infected with SARS-CoV-2 and then Laennec was administered intravenously (4 mL on days 0, 2, 4, and 6 post infection), and the clinical symptoms and viral titers in their respiratory tracts were compared with those of the control group (phosphate buffer solution administration group, days 04 post infection) and the positive control group (remdesivir, a representative COVID-19 drug, administration group, 17.6 mg/kg on day 1 as a loading dose and 8.8 mg/kg daily on days 24 as maintenance doses)

10.1371/journal.pbio.0020075 19 ChristophersonK

To determine LV function, the LCA was occluded for 50 min

Co-localization of GPX4 with neuromelanin was observed in midbrain sections from all 11 control and 12 PD subjects, although neuromelanin was notably reduced in SN of PD midbrain, presumably due to loss of neuromelanin-containing neurons
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