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In terms of glucose metabolism, c-Myc can indirectly promote the expression of monocarboxylate transporter (MCT) 1 and MCT-2(21)

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Salomon and Wilbert H.M

The nitric oxide synthase (NOS) can catalyze NO synthesis from L-arginine, oxygen, NADPH, and NO and can freely diffuse across the cell membrane to induce reactions in adjacent cells (68)

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Apart from the common characteristic of anemia (decrease in red blood cells), anemia due to B12 deficiency presents a process of macrocytosis (increase in the size of red blood cells or erythrocytes) that manifests itself in the abnormal growth of blood cells (the aforementioned megaloblasts), all of which is the result of a failure of their nucleus to mature and an increase in cytoplasmic mass and maturation