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In summary, engaging in regular physical activity, particularly HIIT, is beneficial for women with PCOS, as it not only helps in managing weight but also has positive effects on inflammation, cardiometabolic health, and reproductive function

Multiple studies have reported abnormalities in mitochondrial number, density, and function in skeletal muscle using techniques such as transmission electron microscopy, OXPHOS enzymatic activity analysis, and mitochondrial substrate oxidation measurements [176178]

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Recent studies have demonstrated that RIPostC significantly enhances motor recovery in MCAO mice, exerting neuroprotective effects by regulating DNA 5mC methylation and upregulating BDNF mRNA and protein expression in the motor cortex (95)

Proton magnetic resonance spectroscopy of cerebrospinal fluid in neurodegenerative disease: indication of glial energy impairment in Huntington chorea, but not Parkinson disease

In sum, these findings position iron chelation as a multifaceted interventionsimultaneously vascular, metabolic, and immunologiccapable promoting biological re-equilibration of MDS pathobiology towards a more homeostatic state and justifying further mechanistic and clinical validation