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Wang L, Wang N, Zhang W, et al
Therefore it is possible that zinc treatment leads to decreased enterocyte copper uptake through competition for uptake through ZIP4, although CTR1 is still likely to be the main copper transporter in this cell type based on knockout studies (Nose et al., 2006)
Increased ROS, RNS, and products of oxidation, have been observed both in post-mortem human samples and in SOD1 G93A mice (Carr et al., 2003)
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Put the three together and the pitch is a loop: supply NAD+, protect NAD+, then flip on the pathways that spend it productively
