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TP53 germline mutations Germline mutation of TP53 in the heterozygous LOF form usually presents with a rare autosomally dominant genetic disease with a significantly increased risk of cancer development known as Li-Fraumeni syndrome (LFS)

Biol Reprod 80:7985 Lessey BA (2002) Implantation defects in infertile women with endometriosis

54:1205-14 49 -Gadaleta MN ea.Biochimie 1998;80:863-70 50 -Aureli T ea

A different randomized, double-blind, placebo-controlled clinical trial demonstrated that daily oral administration of equal-lower doses (5 g/day) of l-ARG for a shorter period (6 weeks) compared to the current study induced a significant subjective improvement of penile erectile function, as assessed through standardized OLeary questionnaire for ED, although without a significant improvement of penile vascular parameters assessed by basal PDU, in 29 middle-aged/elderly men affected by organic ED of mixed etiology and unknown severity, therefore reporting, in line with the results of the current study, a discrepancy between subjective and objective improvement in erectile function [28]

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It is most common in men of northern European ancestry, but may be found in men of all ethnicities