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The trial-product estimand is closer to as-treated: it estimates the effect if participants stayed on treatment as intended

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While the ER status has been used to identify breast cancer patients who may respond to TAM, there are still 30%50% of treated Er-positive breast cancer cells that show resistance to TAM ( A study involving the TAM-resistant cells named MCF-7 TR5 (TAM resistant to 5 M) reported that Z-ligustilide can enhance the inhibitory effect of TAM on the cell viability in MCF-7 TR5 and sensitized MCF-7 TR5 cells to TAM via promoting caspase-independent cell death ( TR5 ( Curcumin is a bioactive compound of the Chinese medicine turmeric that exhibits effective anti-cancer activity