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Handbook of Experimental Pharmacology, 195, 187200

After microneedling, use 0.05% concentration only

doi: 10.1007/s12298-022-01211-6

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Notably, serious adverse effects (SAE) in clinical trials may result from dysfunctions of tissues that are highly dependent on IGF-1R signaling for their physiological functions, including muscle, adipose, and bone tissues (46, 55)

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