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Whereas, with increased hepatic steatosis, the transcription factor ATF3 also increases hepatocyte death by inducing RIPK3 expression and changing the TNF-dependent cell death pattern from apoptosis to necroptosis [68]

Because inflammation plays a clear role in the etiology of early AMD (Hageman et al., 2005), our perspective was that CMP had the potential to identify early, pre-cell death signals that are uniquely associated with disease progression as CMP has been used to identify and track heterogeneous cell stress responses in inflammatory lung disease, and identify cell status in tissues prior to the time that clear differences in gene or protein expression are observed (Jean et al., 2003) and has the promise of providing insight into the dynamics of protein transporters (Pow and Robinson, 1994

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The peptide displays a favorable safety profile in preclinical settings with minimal irritation