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Because the brain has the highest mitochondrial energy demand of any organ, even subtle changes in mitochondrial energy production preferentially can affect brain function
L-carnitine supplementation also prevents ventricular enlargement and dysfunction, reduces the infarct size and cardiac biomarkers, and diminishes the total number of cardiac events including cardiac deaths and nonfatal infarction [128, 129]
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In addition, a putative tryptophan-independent pathway of IAA biosynthesis directly from indole has been proposed (Normanly et al., 1993

doi:10.1002/14651858.CD000950 [59] Crill CM, Storm MC, Christensen ML, et al
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