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BH4 Domain of Antiapoptotic Bcl-2 Family Members Closes Voltage-Dependent Anion Channel and Inhibits Apoptotic Mitochondrial Changes and Cell Death

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pS09 and pS10 were constructed as follows

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Beyond GPX4s protection against lipid peroxide-mediated death in conditions like lupus nephritis, the transcription factor NRF2 bolsters cellular redox defenses, while in heart failure, renal proximal tubules sustain high ATP demand through a finely-regulated iron cycleinvolving transferrin endocytosis, DMT1 transport, mitochondrial use, ferritin storage, and ferroportin exportto conserve iron and prevent its urinary loss (119)