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19 It was found that MPTP can freely cross the bloodbrain barrier, is selectively taken up by dopaminergic cells, and inhibits mitochondrial complex 1 function in the respiratory chain, an established factor in the PD pathophysiology

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There is a significant increase in venous thrombosis and fatal stroke risk caused by the use of raloxifene, as well as the problem of intolerable vasomotor stability syndrome (hot flashes), which require clinicians to give comprehensive and careful consideration when using the drug (Ettinger et al., 1999