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Zhang and collaborators showed different mechanisms to explain the differential sorting of DOR (Zhang et al., 2008): when the receptor is phosphorylated by GRK2 and internalized via arrestins it can recycle whereas in a non-phosphorylated form DOR undergoes an arrestin-independent sequestration which is followed by a degradation

Rodent toxicity studies from the Sikiric group have not identified significant acute toxicity

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Its reported biological effects have been investigated primarily in cell culture systems, tissue-level experimental models, and laboratory animal models, rather than in validated clinical settings

Reprod Biomed Online 9:294298

Understanding cellulite removal begins with recognizing its types