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Description
This is reminiscent of a fundamental problem in chemotaxis whereby a cell is able to swim up a gradient of an attractant despite these gradients differing by up to five orders of magnitude

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91 Moreover, no high-quality evidence currently demonstrates that predictive scoring systems improve patient outcomes in a meaningful way, 150 highlighting a persistent gap between prediction and intervention
N.et al (2012)
doi: 10.1016/j.yrtph.2008.01.004
