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Food Reviews International [Internet]

Previous studies have suggested that the major cause of cisplatin-induced ototoxicity is abnormal accumulation of reactive oxygen species (ROS) and oxidative stress

Deshane et al., 2003

Zhang L, Wang H, Xu J, Zhu J, Ding K

Health & Wellness Perimenopause fatigue is real - and surprisingly common

High concentrations of ROS can oxidize mitochondrial proteins, lipids, and nucleic acids, cause cell dysfunction, damage the ability of cells to maintain energy levels, cause energy exhaustion, damage and death of neurons, and change the excitability of neurons, thus reducing the threshold of seizures (6, 7)