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Description
This may occur due to aging, certain diets, or medications such as Metformin, which is commonly used to treat diabetes

Jin CJ, Miners JO, Lillywhite KJ, Mackenzie PI
Journal of Pharmaceutical Sciences 99 , 22002208, doi:10.1002/jps.21989 (2010)

Progressive decline in folate transport efficiency, worsening over time

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The potential role of cannabinoids in dermatology
